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KMID : 0857019990140010145
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Kosin Medical Journal
1999 Volume.14 No. 1 p.145 ~ p.150
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Two Cases of Polymyositis associated with Liver cirrhosis
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Park Hee-Bag
Jang Young-Kwang
Koo Bon-Sam
Kim Hyung-Joo
Jung Yong-Seok
Kim Sung-Hu
Lee Sang-Uk
Han Byung-Hoon
Kim Dae-Seong
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Abstract
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Polymyositis is a nonsuppurative inflammatory muscle disease of unknown etiology. Recently, we have experienced two cases with Polymyositis associated with liver cirrhosis. General weakness, general muscular ache(neck and back), massive hematuria and the marked elevations of CK, LDH, aldolase, and CPK were characteristics clinical findings.
They had previously liver cirrhosis. One patient died soon after admission(due to acute hyperkalemia). One patient was female and she had liver cirrhosis related to HCV infection. The other patient was male in which alcoholic induced liver cirrhosis. He underwent hemodialysis due to acute renal failure. After hemodialysis level of CK, LDH, CPK, and aldolase decreased to normal value. Also BUN, and Cr. values decreased to normal value.
The cause of Polymyositis in cirrhosis are not known yet; However, we suggest that it might be related to the viral infection or combined with autoimmune state.
We present the cases with review of literature; and these cases were rapid progressive disease and needed emergency treatment.
Polymyositis rarely leads to acute renal failure. Two case were reported here, and certain their common features in reported cases are discussed. Given therapeutic advances, these patients should do well despite the dismal prognosis reported in the literature, but early diagnosis and prompt treatment are essential.
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KEYWORD
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Liver cirrhosis, Polymyositis, acute renal failure
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